Dr. Fitzpatrick’s primary research interests lie in the integration and application of multi-scale optical and charged particle imaging technologies -- specifically, biological applications of ion microscopy, development of correlative 3D light and electron microscopy approaches, and new computational tools to visualize and manipulate large-scale multi-dimensional datasets.
1. P.O. Bayguinov, M.R. Fisher, J.A.J. Fitzpatrick. 2020. Assaying Three-Dimensional Cellular Architecture using X-Ray Tomographic and Correlated Imaging Approaches. Journal of Biological Chemistry. 295(46):15782-15793.
2. Z. Deng, G. Maksaev, A.M. Schlegel, J. Zhang, M.J. Rau, J.A.J. Fitzpatrick, E.S. Haswell, P. Yuan. 2020. Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance. Nature Communications. 11(1):3690.
3. Z. Deng, G. Maksaev, M.J. Rau, Z. Xie, H. Hu, J.A.J. Fitzpatrick, P. Yuan. 2020. Gating of Human TRPv3 in a lipid bilayer. Nature Structure and Molecular Biology. 27(7):635-644.
4. S. Pavlovic Djuranovic, J. Erath, R.J. Andrews, P.O. Bayguinov, J.J. Chung, J.A.J. Fitzpatrick, W.N. Moss, P. Szczesny, S. Djuranovic. 2020. Plasmodium falciparum translational machinery condones polyadenosine repeats. eLife 9:e57799.
5. Z. Deng, Z. He, R.M. Bitter, M.J. Rau, J.A.J. Fitzpatrick, P. Yuan. 2020. Cryo-EM structures of the ATP release channel pannexin 1. Nature Structure and Molecular Biology. 27(4):373-381.
6. R. Hervas, M.J. Rau, Y. Park, W. Zhang, A.G. Murzin, J.A.J. Fitzpatrick, S.H.W. Scheres, K. Si. 2020. Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila. Science. 13;367(6483):1230-1234.
7. J.L. Krauss, P.M. Roper, A. Ballard, C.C. Shih, J.A.J. Fitzpatrick, J.E. Cassat, P.Y. Ng, N.J. Pavlos, D.J. Veis. 2019. Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly. MBio. Oct 15;10(5). pii: e02447-19.
8. Y. Guang, T.M. McGrath, N. Klug, R. Nims, C.C. Shih, P.O. Bayguinov, F. Guilak, C.T.N. Pham, J.A.J. Fitzpatrick, L.A. Setton. 2019. Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport Through Joint Synovium to Measure Effective Diffusivity. J Biomech Eng. Sep 1. doi: 10.1115/1.4044892
9. Z. Yang, H. Yan, W. Dai, J. Jing, Y. Yang, S. Mahajan, Y. Zhou, W. Li, C. Macaubas, E.D. Mellins, C.C. Shih, J.A.J. Fitzpatrick, R. Faccio. 2019. Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1. Journal of Autoimmunity. S0896-8411(19)30042-3
10. K.X. Kim, S. Payne, A. Yang-Hood, S.Z. Li, B. Davis, J. Carlquist, B. V-Ghaffari, J.A. Gantz, D. Kallogjeri, J.A.J. Fitzpatrick, K.K. Ohlemiller, K. Hirose, M.A. Rutherford. 2019. Vesicular Glutamatergic Transmission in Noise-induced Loss and Repair of Cochlear Ribbon Synapses. J Neurosci. Mar 29: 2228-18
11. H. Robles, S. Park, M.S. Joens, J.A.J. Fitzpatrick, C.S. Craft, E.L. Scheller. 2019. Characterization of the bone marrow adipocyte niche with three-dimensional electron microscopy. Bone. 118:89-98.
12. S.C. Rogers, L.B. Dosier, T.J. McMahon, H. Zhu, D. Timm, H. Zhang, J. Herbert, J. Atallah, G.M. Palmer, A. Cook, M. Ernst, J. Prakash, M. Terng, P. Towfighi, R. Doctor, A. Said, M.S. Joens, J.A.J. Fitzpatrick, G. Hanna, X. Lin, J.A. Reisz, T. Nemkov, A. D’Alessandro, A. Doctor. 2018. Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes. PLoS One. Dec 21;13(12):e0209201
13. A. Cheruiyot, S. Li, A. Nickless, R. Roth, J.A.J Fitzpatrick, Z. You .2018. Compound C inhibits nonsense-mediated RNA decay independently of AMPK. PLoS One. Oct 5;13(10):e0204978.
14. A.M. Strubberg, D.A. Veronese Paniagua, T. Zhao, L. Dublin, T. Pritchard, P.O. Bayguinov, J.A.J. Fitzpatrick, B.B. Madison. 2018. The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells. Stem Cell Reports. Jul 9. pii: S2213- 6711(18)30272-8.
15. P.O. Baygionov, D.M. Oakley, C.C. Shih, D.J. Geanon, M.S. Joens and J.A.J. Fitzpatrick. 2018. Modern Laser Scanning Confocal Microscopy. Curr Protoc Cytom. Jul;85(1):e39. doi: 10.1002/cpcy.39.
16. M. Hoshi, A. Reginensi, M.S. Joens, J.A.J. Fitzpatrick, H. McNeill, S. Jain. 2018. Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion. J Am Soc Nephrol. Jan 11. pii: ASN.2017040380
17. C.C. Shih, D.M. Oakley, M.S. Joens, R.A. Roth and J.A.J. Fitzpatrick. 2018. Chapter 3: Non-Linear Optical Imaging of Extracellular Matrix Proteins. Methods in Cell Biology. 143:57-78.