Research Abstract

My laboratory is interested in the molecular and cellular bases of neurological and neuropsychiatric disorders. In particular, we are interested in signal transduction pathways mediated by metabotropic glutamate receptors such as mGluR5.... read more

Selected Publications

  • Sergin I, Jong YJ, Harmon SK, Kumar V, O'Malley KL. Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization. J Biol Chem. 2017 Mar 3;292(9):3637-3655.
  • Vincent K, Cornea VM, Jong YJ, Laferrière A, Kumar N, Mickeviciute A, Fung JS, Bandegi P, Ribeiro-da-Silva A, O'Malley KL, Coderre TJ. Intracellular mGluR5 plays a critical role in neuropathic pain. Nat Commun. 2016 Feb 3;7:10604.
  • Purgert CA, Izumi Y, Johng YJ, Kumar V, Zorumski CF, O'Malley KL. Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus. J Neurosci. 2014 Mar 26;34(13):4589-98.
  • Kumar V, Fahey PG, Jong YJ, Ramanan N, O'Malley KL. Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein. J Biol Chem. 2012 Reb 17;287(8):5412-25.
  • Jong YJ, Kumar V, O'Malley KL. Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts. J Biol Chem. 2009 Dec 18;284(51):35827-38.

For a complete list of Dr. O'Malley's publications, click here.

Karen O’Malley, PhD

Professor of Neuroscience

Washington University
School of Medicine
Campus Box 8108
McDonnell Medical Sciences, 913
St. Louis, MO 63110
(314) 747-7087

Other Information

1971 BA, Honors, California State University of Sonoma

1973 MS, Biology, Portland State University (Advisors: Dr. Leonard Simpson, Univ. Oregon, Dr. Robert Terwilliger, Portland State Univ.)

1980 PhD, Biological Sciences, University of Texas in Austin (Advisor: Dr. Karl Folkers)

Selected Honors
1987 Career Research Award for Women, National Science Foundation

1989-1991 Stanley Foundation Investigator, National Alliance for the Mentally Ill

1995 NARSAD Established Investigator Award

2004 Recognition for Excellence in Mentoring

2005 Outstanding Faculty Mentor Award

2006 First Annual AWN Service Award

2007 Outstanding Faculty Postdoctoral Mentor Award

2010 Distinguished Educator Postdoctoral Research Mentoring

2012 Physician and Scientist Leadership Certification

2013 Washington University School of Medicine Alumni Distinguished Faculty Award