Research Abstract

My laboratory is interested in the molecular and cellular bases of neurological and neuropsychiatric disorders. For example, atypical dopamine function has been implicated in disorders such as Parkinson’s disease, drug addiction, affective disorders and Schizophrenia. A current lab emphasis is in determining the mechanisms of cell death in Parkinson’s disease... read more

Selected Publications

  • Hasbani DM, O'Malley KL. Wld(S) mice are protected against the Parkinsonian mimetic MPTP. Exp Neurol. 2006 202:93-99.
  • Holtz WA, Turetzky JM, Jong YJ, O'Malley KL. Oxidative stress-triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics. J Neurochem. 2006 99:54-69.
  • Hasbani DM, Perez FA, Palmiter RD, O'Malley KL. Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo. J Neurosci. 2005 25:9428-9433.
  • Jong YJ, Kumar V, Kingston AE, Romano C, O'Malley KL. Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand. J Biol Chem. 2005 280:30469-30480.
  • Holtz WA, O'Malley KL. Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J Biol Chem. 2003 278:19367-19377.

For a complete list of Dr. Omalley's publications, click here.

Karen O’Malley, PhD

Professor of Neuroscience

Washington University
School of Medicine
Campus Box 8108
McDonnell Medical Sciences, 913
St. Louis, MO 63110
(314) 747-7087

Other Information

1971 BA, Honors, California State University of Sonoma

1973 MS, Biology, Portland State University (Advisors: Dr. Leonard Simpson, Univ. Oregon, Dr. Robert Terwilliger, Portland State Univ.)

1980 PhD, Biological Sciences, University of Texas in Austin (Advisor: Dr. Karl Folkers)

Selected Honors
1987 Career Research Award for Women, National Science Foundation

1989-1991 Stanley Foundation Investigator, National Alliance for the Mentally Ill

1995 NARSAD Established Investigator Award

2004 Recognition for Excellence in Mentoring

2005 Outstanding Faculty Mentor Award

2006 First Annual AWN Service Award

2007 Outstanding Faculty Postdoctoral Mentor Award

2010 Distinguished Educator Postdoctoral Research Mentoring

2012 Physician and Scientist Leadership Certification

2013 Washington University School of Medicine Alumni Distinguished Faculty Award