Department of Neuroscience

Research Abstract

My laboratory is interested in the molecular and cellular bases of neurological and neuropsychiatric disorders. In particular, we are interested in signal transduction pathways mediated by metabotropic glutamate receptors such as mGluR5.... read more

Selected Publications

• Sergin I, Jong YJ, Harmon SK, Kumar V, O'Malley KL. Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization. J Biol Chem. 2017 Mar 3;292(9):3637-3655.
• Vincent K, Cornea VM, Jong YJ, Laferrière A, Kumar N, Mickeviciute A, Fung JS, Bandegi P, Ribeiro-da-Silva A, O'Malley KL, Coderre TJ. Intracellular mGluR5 plays a critical role in neuropathic pain. Nat Commun. 2016 Feb 3;7:10604.
• Purgert CA, Izumi Y, Johng YJ, Kumar V, Zorumski CF, O'Malley KL. Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus. J Neurosci. 2014 Mar 26;34(13):4589-98.
• Kumar V, Fahey PG, Jong YJ, Ramanan N, O'Malley KL. Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein. J Biol Chem. 2012 Reb 17;287(8):5412-25.
• Jong YJ, Kumar V, O'Malley KL. Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts. J Biol Chem. 2009 Dec 18;284(51):35827-38.

For a complete list of Dr. O'Malley's publications, click here.