Research Abstract

Despite the fact that sleep is conserved throughout the animal kingdom, the function of sleep remains one of the last major unsolved biological mysteries facing neuroscience today. Human, rodent and fly studies clearly demonstrate that sleep plays an important role in memory consolidation. However, recent human studies reveal that sleep plays a much more intricate role in brain functioning than simply stabilizing and consolidating memories. Indeed, sleep is vital for the off-line processing of information including improving creative thinking and promoting the discovery of creative insights: An historical example is the discovery of the structure of the benzene ring during a dream. My lab uses the genetic model organism Drosophila melanogaster to elucidate the molecular mechanisms linking sleep to neuronal plasticity. We have demonstrated that we can fully restore cognitive functioning to a diverse set of classic memory mutants simply by enhancing their sleep. In these experiments, sleep was able to reverse cognitive deficits without restoring the causal molecular lesion or structural defect. In addition sleep reversed cognitive deficits in two separate models of Alzheimer’s disease. Current studies are focused on the molecular mechanism that allows sleep to initiate such an extreme form of neuronal plasticity that allows sleep to reverse cognitive deficits even when they are caused by catastrophic genetic and structural lesions.


Selected Publications

  • Dissel, S., Angadi, V., Kirszenblat, L., Suzuki, Y., Donlea, J., Klose, M., Koch, Z., English, D., Winsky-Sommerer, R., van Swinderen, B., et al. (2015). Sleep Restores Behavioral Plasticity to Drosophila Mutants. Curr Biol. May 18;25(10):1270-81
  • Dissel, S., Seugnet, L., Thimgan, M.S., Silverman, N., Angadi, V., Thacher, P.V., Burnham, M.M., and Shaw, P.J. (2014). Differential activation of immune factors in neurons and glia contribute to individual differences in resilience/vulnerability to sleep disruption. Brain, behavior, and immunity. Volume 47, July 2015, Pages 75–85.
  • Donlea J.M., Leahy A., Thimgan M.S., Suzuki Y., Hughson B.N., Sokolowski M.B., Shaw P.J. Foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2613-8. Epub 2012 Jan 30.
  • Donlea JM, Thimgan MS, Suzuki Y, Gottschalk L, Shaw PJ (2011) Inducing sleep by remote control facilitates memory consolidation in Drosophila. Science. 322:1571-1576.
  • Donlea JM, Ramanan N and Shaw PJ. Use-dependent Plasticity in Clock Neurons Regulates Sleep Need in Drosophila. Science. 2009 324: 105-108.
  • Seugnet L, Galvin JE, Suzuki Y, Gottschalk L and Shaw PJ. Persistent short-term memory defects following sleep deprivation in a Drosophila Model of Parkinson’s disease. Sleep. 2009 32(8): 984-992.
  • Seugnet L, SuzukiY, Vine L, Gottschalk L and Shaw PJ. D1 Receptor Activation in the Mushroom Bodies Rescues Sleep-Loss-Induced Learning Impairments in Drosophila. Curr Biol. 2008 Aug 5;18(15):1110-7.
  • Ganguly-Fitzgerald I, Donlea J, Shaw PJ. Waking experience affects sleep need in Drosophila. Science. 2006 313:1775-1781. PMID 16990546.

Paul Shaw, PhD

Associate Professor of Neuroscience

Washington University
School of Medicine
Campus Box 8108
McDonnell Medical Sciences, 970
St. Louis, MO 63110
(314) 362-2703
shawp@wustl.edu

Links

Shaw Lab

Other Information

Education
1985 BA, Psychology & Criminal Justice, Niagara University

1990 MA, Psychology, San Jose State University

1996 PhD, Biopsychology, University of Chicago