Research Abstract

My laboratory seeks to understand the organization, regulation and outputs of circadian neural circuits in the Drosophila brain. We take advantage of the remarkable molecular genetic methods that are available with this model system. Our principal contributions include (i) identifying roles played by the PDF neuropeptide and its receptor: We have analyzed its role genetically, demonstrated it to be a synchronizer of the molecular clock in individual pacemaker neurons under constant conditions... read more


Selected Publications

  • Klose M, Duvall L, Li W, Liang X, Ren C, Steinbach JH, Taghert PH (2016) Functional PDF signaling in the Drosophila circadian neural circuit is gated by RalA dependent modulation. Neuron. In press.
  • Liang, X, Holy, TE, Taghert, PH (2016) Synchronous Drosophila circadian pacemakers display non-synchronous Ca2+ rhythms in vivo. Science (Wash.). 351: 976-981. DOI: 10/1126.
  • Hadžić T., Park D., Abruzzi K.C., Yang L., Trigg J.S., Rohs R., Rosbash M., Taghert PH (2015) Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED. Nucleic Acids Research. doi: 10.1093/nar/gku1377. PMID: 25634895
  • Park, D., Li, P., Dani, A, Taghert PH (2014) Peptidergic Cell-Specific Synaptotagmins in Drosophila: Localization to Dense-Core Granules and Regulation by the bHLH Protein DIMMED. J Neurosci. 34(39):13195-13207.
  • Duvall, LB, Taghert, PH (2012) The circadian neuropeptide PDF signals preferentially through a specific adenylate cyclase isoform AC3 in M pacemakers of Drosophila. PLoS Biology. 10(6): e1001337.
  • Shafer OT, Kim DJ, Dunbar-Yaffe R, Nicholaev V, Lohse M, Taghert PH (2008) Widespread receptivity to neuropeptide PDF throughout the circadian clock network of Drosophila revealed by realtime cAMP imaging. Neuron. 58:223-237 PMID 18439407.
  • Mertens I, Vandingenen A, Johnson EC, Shafer OT, Li W, Trigg JS, De Loof A, Schoofs L, and Taghert PH (2005) PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors. Neuron. 48: 213-219.
  • Allan DW, Park D, St. Pierre DE, Taghert PH, and Thor S (2005) Regulators acting in combinatorial codes also act independently in single differentiating neurons. Neuron. 45:689-700.
  • Lin Y, Han M, Shimada B, Wang L, Gibler TM Amaorone A, Awad T, Stormo GD, Van Gelder RN, Taghert PH (2002) Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster. Proc. Nat. Acad. Sci USA. 99:9562-9567.
  • Renn SCP, Park J, Rosbash M, Hall JC and Taghert PH (1999) A pdf neuropeptide gene mutation and ablation of PDF-containing neurons each cause severe abnormalities of circadian behavioral rhythms in Drosophila. Cell. 99:791-802.

For a complete list of Dr. Taghert's publications, click here.

Paul Taghert, PhD

Professor of Neuroscience

Washington University
School of Medicine
Campus Box 8108
McDonnell Medical Sciences, 469
St. Louis, MO 63110
(314) 362-3641
taghertp@wustl.edu

Other Information

Education
1975 BA, Biology, Reed College, Portland, OR

1981 PhD, Zoology, University of Washington, Seattle, WA (Advisor: James W. Truman)

1981-1984 Postdoctoral Fellow, Stanford University, Stanford, CA (Advisor: Corey S. Goodman)


Selected Honors
1975 Class of 1921 Prize, Reed College

1976-1979 NSF Pre-Doctoral Fellowship

1980 NIH Graduate Trainee

1981-1982 Muscular Dystrophy Association Fellowship

1983-1984 NIH Post-Doctoral Fellowship

1985-1987 Sloan Foundation Fellowship