Neuronal Extrinsic Contribution to Nerve Repair
Decades of research have focused on the signaling pathways elicited in sensory neurons as central intrinsic mechanisms regulating nerve repair. However, we know much less about the contribution of other cells residing in dorsal root ganglia to the nerve repair process. These cells include the glial cells that envelop the neuronal soma, known as satellite glial cells (SGCs), macrophages, endothelial cells and adipocytes.
We are using single-cell RNAseq of DRG in naïve and injured conditions in vivo, to unravel if and how non-neuronal cells respond to injury and actively contribute to the axon regeneration process.